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Prof.
Wolfgang P. Baumeister Wolfgang
Baumeister became famous for his work on the proteasome, the molecular
machine designed for the controlled degradation of intracellular proteins.
His work paved the way for elucidating the structure of this large molecular
machine and its enzymatic mechanism.More recently,
Wolfgang Baumeister and his collaborators developed cryoelectron tomography
which provides three-dimensional images of intact cells at high resolution
and with it new vistas of their supramolecular architecture. The potential
of this method for unraveling the network of molecular interactions
which underlie higher cellular functions is huge, since a tomogram of
a cell at high resolution is essentially a three-dimensional image of
its entire proteome.
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